Meclofenamic acid represses spermatogonial proliferation through modulating m6A RNA modification
نویسندگان
چکیده
منابع مشابه
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5, oxidatively demethylate abundant N(6)-methyladenosine (m(6)A) residues in mRNA. Achieving a method for selective inhibition of FTO over ALKBH5 remains a challenge, however. Here, we have identified meclofenamic acid (MA) as a highly selective inhibitor of FTO. MA is a non-steroidal, anti-inflammatory drug that ...
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ژورنال
عنوان ژورنال: Journal of Animal Science and Biotechnology
سال: 2019
ISSN: 2049-1891
DOI: 10.1186/s40104-019-0361-6